background: central renin angiotensin system has an important role on the cerebral microcirculation and metabolism. our previous work showed that inhibition of angiotensin converting enzyme (ace) activity prior to induction of ischemia protected the brain from severe ischemia/reperfusion (i/r) injuries. this study evaluated the impacts of post-ischemic inhibition of ace, enalapril, on brain inf...

background: renal ischemia reperfusion (ir) injury has been a major source of concern during the past decades and angiotensin converting enzyme (ace) inhibitors have been successfully used to prevent this injury. there have been some controversial reports about the involvement of katp channels in the mechanism of action of ace inhibitors. in this study, we examined the effect of katp channel bl...

background: sarcoidosis is a multisystem inflammatory disease of unknown origin with characterization of small granulomas. angiotensin-converting enzyme (ace) is a pathophysiologic marker of sarcoidosis. we present the ace insertion/deletion (i/d) polymorphism in correlation with serum ace level in iranian patients with sarcoidosis. methods: from jan 2014 to jan 2015, 102 iranian patients who h...

results the ace inhibitory activities of hydroalcoholic extracts were as follows; m. vulgare > n. jatamansi > p. ferulacea. the least ic50 value was related to the hydroalcoholic extract of m. vulgare (0.791 mg/ml). the ic50 values of n. jatamansi and p. ferulacea were 2.147 and 4.057 mg/ml, respectively. conclusions the results supported the traditional antihypertensive use of these plants, es...

introduction: in patients with uncomplicated primary hypertension (htn), angiotensin converting enzyme inhibitors (aceis) are considered as monotherapy. in some studies, cough was not related to age, sex, underlying disease, or drug dosage. however, in previous studies, the incidence of cough was greater in females than males. the aim of this study is to determine the incidence of captopril-ind...

conclusions traditional medicine based on certain plants could be of beneficial effects in hypertension treatment. results in total, 52 species out of the 135 (39%) screened, gave more than 50% ace inhibition. forty species were found to possess a high ace inhibiting ability and were low in their tannin content. materials and methods in the present study 135 plants used in traditional persian m...

purpose it is well known that the effects of exercise training gives inter individual differences which might be due to genetic diversity. this study aims to explore the probable relation between angiotensin converting enzyme (ace) alleles and physical fitness parameters in elite athletes. methods twenty-nine national level indian army triathletes who volunteered for the study were taken as sub...

Angiotensin-converting enzyme (ACE) plays an important role in regulating blood pressure the body by converting angiotensin-I into angiotensin-II. It is basic component of Renin angiotensin aldosterone system (RAAS), imbalance RAAS may leads to many cardiovascular and renal diseases. There are marketed available drugs for inhibition ACE, but prolonged use some cause progressive side effects. Re...

background: early diagnosis of albuminuria and the prevention of its progression to macroalbuminuria and diabetic nephropathy are crucial. angiotensin converting enzyme inhibitors (aceis) and antagonists of angiotensin ii receptors type i (arbs) are currently used as first-line treatment for albuminuria in these patients. the present study was conducted to assess the efficacy of addition of spi...

BUMC PROCEEDINGS 2003;16:123–126 The angiotensin II receptor blockers (ARBs) represent a newer class of antihypertensive agents. Their mechanism of action differs from that of the angiotensin-converting enzyme (ACE) inhibitors, which also affect the renin-angiotensin system. The ARBs were developed to overcome several of the deficiencies of ACE inhibitors: competitive inhibition of ACE results ...